Savara Pharmaceuticals is an emerging specialty pharmaceutical company developing innovative pulmonary drugs for the treatment of serious and life-threatening conditions.
Inhaled antibiotics are becoming the cornerstone of treatment in patients with cystic fibrosis and other chronic care patients who experience frequent lung infections, specifically Pseudomonas aeruginosa infections. Despite these advancements, there are currently no approved inhaled drugs to treat methicillin-resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis―a life-threatening infection known to shorten the lives of affected patients. Vancomycin administered intravenously is the antibiotic of choice for the treatment of MRSA-related bronchopneumonia in cystic fibrosis patients, however, this method does not achieve optimal penetration into the lungs and systemic toxicities limit its use in a chronic setting.
Savara Pharmaceuticals’ lead product candidate is AeroVanc™ (vancomycin hydrochloride inhalation powder), the first inhaled antibiotic being developed to address the growing population of MRSA-infected cystic fibrosis patients. By delivering vancomycin directly to the site of infection, AeroVanc has the ability to improve clinical efficacy and reduce adverse effects caused by broad-spectrum antibiotics.